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Norvasc |
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Amlodipine
(as besylate, mesylate or maleate) is a long-acting calcium channel
blocker (dihydropyridine) used as an anti-hypertensive and in the
treatment of angina. As other calcium channel blockers, amlodipine acts
by relaxing the smooth muscle in the arterial wall, decreasing
peripheral resistance and hence reducing blood pressure; in angina it
increases blood flow to the heart muscle. Amlodipine is marketed as Norvasc in North America and as Istin in the United Kingdom by Pfizer as well as under various other names. Indications
Hypertension or angina: 5 or 10 mg once daily. Salts In the United Kingdom tablets of amlodipine from different suppliers may contain different salts. The strength of the tablets is expressed in terms of amlodipine base. i.e. without the salt. Tablets containing different salts are therefore considered interchangeable. Drug Metabolism and Excretion Amlodipine is almost entirely metabolised to inactive metabolites. Ten per cent of the parent substance and 60% of the metabolites are excreted in urine. |
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